diff --git a/build/gobind/monolith.go b/build/gobind/monolith.go
index e43734900..a4803396f 100644
--- a/build/gobind/monolith.go
+++ b/build/gobind/monolith.go
@@ -18,7 +18,6 @@ import (
 	"github.com/matrix-org/dendrite/federationsender"
 	"github.com/matrix-org/dendrite/federationsender/api"
 	"github.com/matrix-org/dendrite/internal/config"
-	"github.com/matrix-org/dendrite/internal/httputil"
 	"github.com/matrix-org/dendrite/internal/setup"
 	"github.com/matrix-org/dendrite/keyserver"
 	"github.com/matrix-org/dendrite/roomserver"
@@ -172,14 +171,6 @@ func (m *DendriteMonolith) Start() {
 	}
 	monolith.AddAllPublicRoutes(base.PublicAPIMux)
 
-	httputil.SetupHTTPAPI(
-		base.BaseMux,
-		base.PublicAPIMux,
-		base.InternalAPIMux,
-		&cfg.Global,
-		base.UseHTTPAPIs,
-	)
-
 	// Build both ends of a HTTP multiplex.
 	m.httpServer = &http.Server{
 		Addr:         ":0",
@@ -190,7 +181,7 @@ func (m *DendriteMonolith) Start() {
 		BaseContext: func(_ net.Listener) context.Context {
 			return context.Background()
 		},
-		Handler: base.BaseMux,
+		Handler: base.PublicAPIMux,
 	}
 
 	go func() {
diff --git a/cmd/dendrite-demo-libp2p/main.go b/cmd/dendrite-demo-libp2p/main.go
index e30355476..5379a7cd8 100644
--- a/cmd/dendrite-demo-libp2p/main.go
+++ b/cmd/dendrite-demo-libp2p/main.go
@@ -31,7 +31,6 @@ import (
 	"github.com/matrix-org/dendrite/eduserver"
 	"github.com/matrix-org/dendrite/federationsender"
 	"github.com/matrix-org/dendrite/internal/config"
-	"github.com/matrix-org/dendrite/internal/httputil"
 	"github.com/matrix-org/dendrite/internal/setup"
 	"github.com/matrix-org/dendrite/keyserver"
 	"github.com/matrix-org/dendrite/roomserver"
@@ -192,19 +191,11 @@ func main() {
 	}
 	monolith.AddAllPublicRoutes(base.Base.PublicAPIMux)
 
-	httputil.SetupHTTPAPI(
-		base.Base.BaseMux,
-		base.Base.PublicAPIMux,
-		base.Base.InternalAPIMux,
-		&cfg.Global,
-		base.Base.UseHTTPAPIs,
-	)
-
 	// Expose the matrix APIs directly rather than putting them under a /api path.
 	go func() {
 		httpBindAddr := fmt.Sprintf(":%d", *instancePort)
 		logrus.Info("Listening on ", httpBindAddr)
-		logrus.Fatal(http.ListenAndServe(httpBindAddr, base.Base.BaseMux))
+		logrus.Fatal(http.ListenAndServe(httpBindAddr, base.Base.PublicAPIMux))
 	}()
 	// Expose the matrix APIs also via libp2p
 	if base.LibP2P != nil {
@@ -217,7 +208,7 @@ func main() {
 			defer func() {
 				logrus.Fatal(listener.Close())
 			}()
-			logrus.Fatal(http.Serve(listener, base.Base.BaseMux))
+			logrus.Fatal(http.Serve(listener, base.Base.PublicAPIMux))
 		}()
 	}
 
diff --git a/cmd/dendrite-demo-yggdrasil/main.go b/cmd/dendrite-demo-yggdrasil/main.go
index 33ed15429..1014912ca 100644
--- a/cmd/dendrite-demo-yggdrasil/main.go
+++ b/cmd/dendrite-demo-yggdrasil/main.go
@@ -35,7 +35,6 @@ import (
 	"github.com/matrix-org/dendrite/federationsender/api"
 	"github.com/matrix-org/dendrite/internal"
 	"github.com/matrix-org/dendrite/internal/config"
-	"github.com/matrix-org/dendrite/internal/httputil"
 	"github.com/matrix-org/dendrite/internal/setup"
 	"github.com/matrix-org/dendrite/keyserver"
 	"github.com/matrix-org/dendrite/roomserver"
@@ -132,7 +131,7 @@ func main() {
 
 	rsComponent.SetFederationSenderAPI(fsAPI)
 
-	embed.Embed(base.BaseMux, *instancePort, "Yggdrasil Demo")
+	embed.Embed(base.PublicAPIMux, *instancePort, "Yggdrasil Demo")
 
 	monolith := setup.Monolith{
 		Config:        base.Cfg,
@@ -157,14 +156,6 @@ func main() {
 	}
 	monolith.AddAllPublicRoutes(base.PublicAPIMux)
 
-	httputil.SetupHTTPAPI(
-		base.BaseMux,
-		base.PublicAPIMux,
-		base.InternalAPIMux,
-		&cfg.Global,
-		base.UseHTTPAPIs,
-	)
-
 	// Build both ends of a HTTP multiplex.
 	httpServer := &http.Server{
 		Addr:         ":0",
@@ -175,7 +166,7 @@ func main() {
 		BaseContext: func(_ net.Listener) context.Context {
 			return context.Background()
 		},
-		Handler: base.BaseMux,
+		Handler: base.PublicAPIMux,
 	}
 
 	go func() {
@@ -185,7 +176,7 @@ func main() {
 	go func() {
 		httpBindAddr := fmt.Sprintf(":%d", *instancePort)
 		logrus.Info("Listening on ", httpBindAddr)
-		logrus.Fatal(http.ListenAndServe(httpBindAddr, base.BaseMux))
+		logrus.Fatal(http.ListenAndServe(httpBindAddr, base.PublicAPIMux))
 	}()
 	go func() {
 		logrus.Info("Sending wake-up message to known nodes")
diff --git a/cmd/dendritejs/main.go b/cmd/dendritejs/main.go
index f350a938b..70abcb4ba 100644
--- a/cmd/dendritejs/main.go
+++ b/cmd/dendritejs/main.go
@@ -21,6 +21,7 @@ import (
 	"fmt"
 	"syscall/js"
 
+	"github.com/gorilla/mux"
 	"github.com/matrix-org/dendrite/appservice"
 	"github.com/matrix-org/dendrite/currentstateserver"
 	"github.com/matrix-org/dendrite/eduserver"
@@ -236,20 +237,16 @@ func main() {
 	}
 	monolith.AddAllPublicRoutes(base.PublicAPIMux)
 
-	httputil.SetupHTTPAPI(
-		base.BaseMux,
-		base.PublicAPIMux,
-		base.InternalAPIMux,
-		&cfg.Global,
-		base.UseHTTPAPIs,
-	)
+	router := mux.NewRouter()
+	router.PathPrefix(httputil.InternalPathPrefix).Handler(base.InternalAPIMux)
+	router.PathPrefix(httputil.PublicPathPrefix).Handler(base.PublicAPIMux)
 
 	// Expose the matrix APIs via libp2p-js - for federation traffic
 	if node != nil {
 		go func() {
 			logrus.Info("Listening on libp2p-js host ID ", node.Id)
 			s := JSServer{
-				Mux: base.BaseMux,
+				Mux: base.PublicAPIMux,
 			}
 			s.ListenAndServe("p2p")
 		}()
@@ -259,7 +256,7 @@ func main() {
 	go func() {
 		logrus.Info("Listening for service-worker fetch traffic")
 		s := JSServer{
-			Mux: base.BaseMux,
+			Mux: router,
 		}
 		s.ListenAndServe("fetch")
 	}()
diff --git a/federationapi/federationapi_test.go b/federationapi/federationapi_test.go
index 331d33294..e73dcd29e 100644
--- a/federationapi/federationapi_test.go
+++ b/federationapi/federationapi_test.go
@@ -8,7 +8,6 @@ import (
 
 	"github.com/matrix-org/dendrite/federationapi"
 	"github.com/matrix-org/dendrite/internal/config"
-	"github.com/matrix-org/dendrite/internal/httputil"
 	"github.com/matrix-org/dendrite/internal/setup"
 	"github.com/matrix-org/dendrite/internal/test"
 	"github.com/matrix-org/gomatrix"
@@ -33,14 +32,7 @@ func TestRoomsV3URLEscapeDoNot404(t *testing.T) {
 	// TODO: This is pretty fragile, as if anything calls anything on these nils this test will break.
 	// Unfortunately, it makes little sense to instantiate these dependencies when we just want to test routing.
 	federationapi.AddPublicRoutes(base.PublicAPIMux, &cfg.FederationAPI, nil, nil, keyRing, nil, fsAPI, nil, nil, nil)
-	httputil.SetupHTTPAPI(
-		base.BaseMux,
-		base.PublicAPIMux,
-		base.InternalAPIMux,
-		&cfg.Global,
-		base.UseHTTPAPIs,
-	)
-	baseURL, cancel := test.ListenAndServe(t, base.BaseMux, true)
+	baseURL, cancel := test.ListenAndServe(t, base.PublicAPIMux, true)
 	defer cancel()
 	serverName := gomatrixserverlib.ServerName(strings.TrimPrefix(baseURL, "https://"))
 
diff --git a/internal/httputil/paths.go b/internal/httputil/paths.go
index 965abd306..728b5a871 100644
--- a/internal/httputil/paths.go
+++ b/internal/httputil/paths.go
@@ -15,6 +15,6 @@
 package httputil
 
 const (
-	PublicPathPrefix   = "/_matrix"
-	InternalPathPrefix = "/api"
+	PublicPathPrefix   = "/_matrix/"
+	InternalPathPrefix = "/api/"
 )